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The high activity of 30 prompted a synthesis of the corresponding disulfide 32 with a 14-membered ring system anticipated be able to adopt a similar trans conformation as 30

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The main ways that peptide nasal sprays and injectable peptides differ are in how they are delivered and how convenient they are

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In summary, while we understand that there are no head-to-head trials comparing REBYOTA TM to ZINPLAVA TM , additional information would help inform our assessment of whether REBYOTA TM demonstrates a substantial clinical improvement over existing technologies